F.O.C.R.	Familial Ovarian Cancer Register
	Achievements Recently, an update leaflet with the summary of what has been achieved so far was compiled. Get the update in Adobe Acrobat PDF format. Findings from the study have been published in 21 research papers in well-known scientific and medical journals and listed below. Ramus SJ, Harrington PA, Pye C, DiCioccio RA, Cox MJ, Garlinghouse-Jones K, et al. (2007) The contribution of BRCA1 and BRCA2 mutations to inherited ovarian cancer. Hum Mutat 0,1-9,2007 get [PDF] Ramus SJ, Harrington PA, Pye C, Peock S, Cook MR, Cox MJ, et al. (2007) Screening for the BRCA1-ins6kbEx13 mutation: potential for misdiagnosis. Hum Mutat 28(5):525-6. get [PDF] Whittemore AS, Balise RR, Pharoah PDP, DiCioccio RA, Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Oakley-Girvan I, Ramus S, Daly M, Usinowicz M, Garlinghouse-Jones K, Ponder BAJ, Buys S, Senie R, Andrulis I, John E, Hopper J, Piver S (2004) Oral contraceptive use and ovarian cancer risk among carriers of BRCA1 or BRCA2 mutations. Br J Cancer 91:1911-15. get [PDF] Lakhani SR, Manek S, Penault-Llorca F, Flannagan A, Arnout L, Merrett S, McGuffog L, et al. (2004)The pathology of ovarian cancers in BRCA1 and BRCA2 carriers - a UKCCCR/BCLC Collaborative study. Clinical Cancer Research 10:2473-2481 get [PDF] Ramus SJ, Pharoah PD, Harrington P, Pye C, Werness B, Bobrow L, Ayhan A, Wells D, Fishman A, Gore M, DiCioccio RA, Piver MS, Whittemore AS, Ponder BA, Gayther SA (2003) BRCA1/2 mutation status influences somatic genetic progression in inherited and sporadic epithelial ovarian cancer cases. Cancer Res 63:417-23. get [PDF] Pharoah PD, Ponder BA (2002) The genetics of ovarian cancer. Best Pract Res Clin Obstet Gynaecol 16:449-68. Antoniou AC, Gayther SA, Stratton JF, Ponder BAJ, Easton DF (2000) Risk models for familial breast and ovarian cancer. Genetic Epidemiology 18:173-190. Sutcliffe S, Pharoah PD, Easton DF, Ponder BA (2000) Ovarian and breast cancer risks to women in families with two or more cases of ovarian cancer. Int J Cancer 87:110-7. get [PDF] Werness BA, Ramus SJ, Whittemore AS, Garlinghouse-Jones K, Oakley-Girvan I, Dicioccio RA, Tsukada Y, Ponder BA, Piver MS (2000) Histopathology of familial ovarian tumours in women from families with and without germline BRCA1 mutations. Hum Pathol 31:1420-4. Gayther SA, Russell P, Harrington P, Antoniou A, Easton DF, Ponder BAJ (1999) The contribution of germline BRCA1 and BRCA2 mutations to familial ovarian cancer : No evidence for other ovarian cancer-susceptibility genes. Am J Hum Genet 65:1021-1029. get [PDF] Pharoah PDP, Easton DF, Stockton DL, Gayther SA, Ponder BAJ (1999) Survival in familial, BRCA1 and BRCA2 associated epithelial ovarian cancer. Cancer Res 59:868-871. get [PDF] Ramus SJ, Bobrow LG, Pharoah PDP, Finnigan DS, Fishman A, Altaras M, Harrington PA, Gayther SA, Ponder BAJ, Friedman LS (1999) Increased frequency of tp53 mutations in BRCA1 and BRCA2 ovarian tumours. Genes Chromosomes and Cancer 25:91-96. get [PDF] Narod SA, Risch H, Moslehi R, Dorum A, Neuhausen S, Olsson H, Provencher D, Radice P, Evans G, Bishop S, Brunet JS, Ponder BA, Hereditary Ovarian Cancer Clinical Study Group (1998) Oral contraceptives and the risk of hereditary ovarian cancer. N Engl J Med 339:424-8. get [PDF] Gayther SA, Mangion J, Russell P, Seal S, Barfoot R, Ponder BA, Stratton MR, Easton D (1997) Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene. Nature Genetics 15:103-105. Ramus SJ, Friedman LS, Gayther SA, Ponder BA, Bobrow L, van der Looji M, Papp J, Olah E (1997) A breast/ovarian cancer patient with germline mutations in both BRCA1 and BRCA2 [letter]. Nature Genetics 15:14-15. Gayther SA, Russell P, Harrington P, Pharoah PDP, Foster K, DiCioccio D, Easton DF, Ponder BAJ (1996) High frequency of germline BRCA1 and BRCA2 mutations in familial ovarian cancer. American Journal of Human Genetics 59:A35. Gayther SA, Harrington P, Russell P, Kharkevich G, Garkavtseva RF, Ponder BAJ, UKCCCR Familial Ovarian Cancer Study Group Rapid detection of regionally clustered germ-line BRCA1 mutations by multiplex heteroduplex analysis. American Journal of Human Genetics 58:451-456. Phelan CM, Rebbeck TR, Weber BL, Devilee P, Ruttledge MH, Lynch HT, Lenoir GM, Stratton MR, Easton DF, Ponder BA, Cannon Albright L, Larsson C, Goldgar DE, Narod SA (1996) Ovarian cancer risk in BRCA1 carriers is modified by the HRAS1 variable number of tandem repeat (VNTR) locus. Nature Genetics 12:309-311. Chang J, Fryatt I, Ponder B, Fisher C, Gore ME (1995) A matched control study of familial epithelial ovarian cancer: patient characteristics, response to chemotherapy and outcome. Ann.Oncol. 6:80-82. Gayther SA, Warren W, Mazoyer S, Russell PA, Harrington PA, Chiano M, Seal S, Hamoudi R, van Rensburg EJ, Dunning AM, Love R, Evans G, Easton D, Clayton C, Stratton MR, Ponder BAJ (1995) Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype-phenotype correlation. Nature Genetics 11:428-433. Smith SA, Easton DF, Evans DGR, Ponder BAJ (1992) Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome. Nature Genetics 2:128-131.
Last update 7th September 2007	Contact the web master	About this site