This Web site provides access to BOADICEA Web Application versions 1.0 and 2.0. Users should cite the following paper when describing results generated with these programs:

Antoniou A.C., Cunningham A.P., Peto J., Evans D.G., Lalloo F., Narod S.A., Risch H.A., Eyfjord J.E., Hopper J.L., Southey M.C., Olsson H., Johannsson O., Borg A., Passini B., Radice P., Manoukian S., Eccles D.M., Tang N., Olah E., Anton-Culver H., Warner E., Lubinski J., Gronwald J., Gorski B., Tryggvadottir L., Syrjakoski K., Kallioniemi O-P., Eerola H., Nevanlinna H., Pharoah P.D.P. and Easton D.F., The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions, British Journal of Cancer, advance online publication 18 March 2008 (doi: 10.1038/sj.bjc.6604305).

To access this paper via PubMed click here

A validation study describing the performance of BOADICEA and other risk models has been published recently in the Journal of Medical Genetics:

Antoniou A., Hardy R., Walker L., Evans D.G., Shenton A., Eeles R., Shanley S., Pichert G., Izatt L., Rose S., Douglas F., Eccles D., Morrison P., Scott J., Zimmern R., Easton D. and Pharoah P., Predicting the likelihood of carrying a BRCA1 or BRCA2 mutation: validation of BOADICEA, BRCAPRO, IBIS, Myriad and the Manchester scoring system using data from UK genetics clinics, Journal of Medical Genetics, advance online publication 15 April 2008 (doi:10.1136/jmg.2007.056556).

To access this paper via PubMed click here

An eariler version of the BOADICEA model is described in the following papers:

Antoniou A.C., Pharoah P.P.D., Smith P. & Easton D.F. 2004. The BOADICEA model of genetic susceptibility to breast and ovarian cancer, British Journal of Cancer, 91(8), 1580-1590.

Antoniou A.C. and Easton D.F. 2006. Risk prediction models for familial breast cancer, Future Oncology, 2(2), 257-274.

Antoniou A.C., Durocher F., Smith P., Simard J., INHERIT BRCAs program members and Easton D. 2006. BRCA1 and BRCA2 mutation predictions using the BOADICEA and BRCAPRO models and penetrance estimation in high-risk French-Canadian families, Breast Cancer Research, 8(R3), doi:10.1186/bcr1365.

Barcenas C.H., Hosain G.M.M., Arun B., Zong J.H., Zhou X.J., Chen J.F., Cortada J.M., Mills G.B., Tomlinson G.E., Miller A.R., Strong L.C. and Amos C.I. 2006. Assessing BRCA carrier probabilities in extended families, Journal of Clinical Oncology, 24(3), 354-360.