Non-Communicable Disease (NCD) Research Group

Manjinder Sandhu, Elizabeth Young, Nicholas Wainwright and Theodore Papamarkou

The integration of principles and procedures underlying population genetics and epidemiology, together with current and emerging genome-wide technologies, provides unparalleled opportunities to identify the biological mechanisms underlying the development of complex diseases. Complementing gene-centric approaches to assess the genetic basis of common diseases, genome-wide association studies provide a research strategy to discover new genetic determinants of quantitative traits and risk factors underlying complex diseases, including cardiometabolic risk factors and related diseases. As well as providing new insights into disease aetiology, these studies provide a research framework to develop genetic tools for causal inference in the context of Mendelian randomisation studies. Our group focusses on the analysis and exploration of these data.