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Stephen Burgess, Simon G Thompson, CRP CHD Genetics CollaborationAuthors/Writing committee: S. Burgess, M. R. C Biostatistics UnitCambridge;, S. G. Thompson, M. R. C Biostatistics UnitCambridge. Both authors are supported by the U.K. Medical Research Council (grant U.1052.00.001). Authors/Steering group Atherosclerosis Risk in Communities Study (A. R. I. C): G. AndrewsUniversity of North Carolina. B. H. F/M. R. C Family Heart, GRACE Studies: N. J. Samani, University of Leicester, A. Hall, University of Leeds. British Regional Heart Study (B. R. H. S): P. Whincup, R. Morris, University College London. British Women's Heart, Health Study (BWHHS): D. A. Lawlor, G. Davey Smith, N. Timpson, University of Bristol; S. EbrahimLondon School of Hygiene, Tropical Medicine. Caerphilly Study: Y. Ben?Shlomo, G. Davey Smith, N. Timpson, University of Bristol. Cambridge Heart Antioxidant Study (C. H. A. O. S): M. BrownS. Ricketts, M. Sandhu, University of Cambridge. Cardiovascular Health Study (C. H. S): A. Reiner, B. Psaty, University of Washington; L. LangeUniversity of North Carolina; M. CushmanUniversity of Vermont. Carotid Ultrasound Disease Assessment Study (C. U. D. A. S), Carotid Ultrasound in Patients with Ischaemic Heart Disease (CUPID): J. Hung, P. ThompsonJ. Beilby,, N. Warrington, University of Western Australia; L. J. PalmerWestern Australia Institute for Medical Research. Copenhagen City Heart Study (C. C. H. S)Copenhagen General Population Study (C. G. P. S), Copenhagen Ischaemic Heart Disease Study (CIHDS): B. G. Nordestgaard, A. Tybjaerg?Hansen, J. Zacho, University of Copenhagen. C. R. P Gene Variants, Coronary Artery Disease in a Chinese Han Population (CRP?Han): C. Wu, Shanghai Institute of Cardiovascular Disease. Edinburgh Artery Study (E. A. S): G. LoweUniversity of Glasgow; I. TzoulakiImperial College London. English Longitudinal Study of Aging (E. L. S. A): M. KumariUniversity College London. European Prospective Investigation into Cancer, Nutrition (EPIC), Norfolk Centre: M. SandhuUniversity of Cambridge. Framingham Offspring Study: J. F. YamamotoBoston University. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Micardico (G. I. S. S. I): B. ChiodiniKing's College London, M. Franzosi, Mario Negri Institute for Pharmacological Research. Health in Men Study (H. I. M. S): G.J. HankeyUniversity of Western Australia; K. JamrozikUniversity of Queensland; L. PalmerWestern Australia Institute for Medical Research. Health Professionals Follow?up Study (H. P. F. S): E. Rimm, J. Pai, Harvard School of Public Health. Heart, Vascular Health Study: B. Psaty, S. Heckbert, J. Bis, University of Washington. I. N. T. E. R. H. E. A. R. T Study: S. AnandMcMaster University; J. EngertMcGill University. International Study of Infarct Survival (I. S. I. S): R. Collins, R. Clarke, University of Oxford. Malmo Diet, Cancer Study: O. Melander, Malmo University Hospital; G. BerglundUniversity of Lund. Northern Swedish Cohorts Study: P. LadenvallOstra Sjukhuset Goteborg; L. Johansson, J.?H. Jansson, Skelleftea Hospital; G. HallmansUmea University. Northwick Park Heart?I. I Study: A. Hingorani, S. Humphries, University College London. Nurses' Health Study (N. H. S): E. RimmJ. Manson, J. Pai, Harvard School of Public Health, Harvard Medical School. Prococious Coronary Artery Disease Study (PROCARDIS): H. Watkins, R. Clarke, J. Hopewell, University of Oxford. Pakistan Risk of Myocardial Infarction Study (P. R. O. M. I. S): D. Saleheen, R. Frossard, Center for Non?Communicable Diseases; J. DaneshUniversity of Cambridge. Prospective Study of Pravastatin in the Elderly at Risk (P. R. O. S. P. E. R): N. SattarM. Robertson, J. Shepherd, University of Glasgow; E. SchaeferTufts University. Rotterdam Study: A. HofmanJ.C.M. Witteman, I. Kardys, Erasmus University Medical Centre. Speedwell Study: Y. Ben?ShlomoG. Davey Smith, N. Timpson, Universi. (2010) Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables. Stat Med Mar ():.

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