EPIC-Norfolk Collaborators

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Collaborating Researchers

Andersson | Atkin | Boekholdt | Brayne | Broadway | Bruce | Chatterjee | Danesh | Dowsett | Dunning | Easton | Ekelund | Ellegard | Forouhi | Foster | Friesen | Fruchart | Griffin | Guralnik | Hart | Hogervorst | Humphries | HuppertKastelein | Key | Kuhnle | Langenberg | Loos | Melzer | Michels | Ong | O'Rahilly |
Otvos | Pharoah | Ponder | Reeve | Reitsma | Riboli
Sahakian | Sandhu | Schatzkin | ShukerSurtees | Symmons | Todd | Varki | Wainwright | Warren | Witztum | Wong



Andersson, Susan
Dr Susan Andersson and Dr Lars Ellegard, of Department of Clinical Nutrition, Sahlgrenska Academy at Göteborg University, Sweden have worked with EPIC to look at how plant sterol intake from naturally occurring dietary sources impacts on the concentrations of blood lipids.

Atkin, Wendy
Dr Wendy Atkin with the help of Mark Watson and Dr Hugh Kennedy carried out sigmoidoscopies for for the Flexi-Scope Trial, a multicentre trial taking place in the United Kingdom through what was then called the Imperial Cancer Research Fund (Cancer Research UK).

The aim of this trial was to look at the effectiveness, acceptability and feasibility of screening for bowel cancer at age 60 years and to explore methods of identifying such cancers at an early stage in thier development.

The Norfolk arm of the trial took place at the same time as our second health check between 1997 and 2000.  Around 1000 EPIC participants independently took part in both studies.  It is very rare for two such large studies to overlap in this way, and so this was a unique opportunity for the two studies to collaborate.  The biopsies taken from EPIC participants were analysed using the data on diet, lifestyle and health already collected as part of their inolvement with EPIC, and associations with DNA damage markers.

The final outcome showed an increased risk of bowel polyps from eating red meat, with no effects of the genetic influences that were studied.



Boekholdt, Matthijs
Dr Matthijs Boekholdt from Department of Cardiology, Academic Medical Center, Amsterdam, is working with EPIC-Norfolk to investigate the role of a novel biomarkers as well as inflammatory markers such as macrophage migration inhibitory factor (MIF), myeloperoxidase (MPO) and Interleukin 8 (IL8) in coronary heart disease and other chronic diseases.

Brayne, Carol
Professor Brayne is an epidemiologist and public health physician at the Department of Health and Public Care, University of Cambridge. Professor Brayne's research interests include dementia, healthy ageing and neuropsychiatric epidemiology. Professor Brayne is the lead Principle Investigator of the Cognitive Function and Ageing Study (CFAS), a large UK-based longitudinal multicentre study looking at the health and cognitive function of older people. Professor Brayne is leading on the area of cognition for the EPIC Third Health Check.

Broadway, David
Mr David Broadway, from Norfolk and Norwich University Hospital is also working on visual health and treats all participants with an abnormal eye result from the Third Health Check.

Bruce, Ian
Professor Deborah Symmons and Dr Ian Bruce of the Arthritis Research Campaign (ARC) Epidemiology Unit, University of Manchester, have used EPIC dietary data collected at baseline to see whether there is an association between consumption diet and the risk of developing inflammatory polyarthritis (IP).

Chatterjee, Krishna
Professor Krishna Chatterjee of the Department of Medicine, University of Cambridge, measured thyroid stimulating hormone (TSH) and free thyroxine (FT4) in blood samples collected at Baseline.  This data was used to assess association between thyroid hormone levels and risk factors of chronic diseases.

Danesh, John
Professor John Danesh, Head of the Department of Health and Public CareUniversity of Cambridge, leads on EPIC-Heart, the cardio-vascular component of the wider European Study. The objective of EPIC-Heart is to advance understanding about the separate and combined influences of lifestyle (especially dietary), environmental, metabolic and genetic factors in the development of cardiovascular diseases.

Dowsett, Mitch
Professor Mitch Dowsett, from Royal Marsden NHS Trust, London measured sex hormones in blood samples collected at baseline and worked with EPIC-Norfolk to look at the relationship between endogenous sex hormone concentrations and health in men and women.

Dunning, Alison
Professor Doug Easton and Dr Alison Dunning of Cancer Research UK Genetic Epidemiology Research Group are using the EPIC-Norfolk data to identify and characterise genes that predispose to cancer in the general population and estimating the cancer risk in predisposed individuals.

Easton, Douglas
Professor Doug Easton and Dr Alison Dunning of Cancer Research UK Genetic Epidemiology Research Group are using the EPIC-Norfolk data to identify and characterise genes that predispose to cancer in the general population and estimating the cancer risk in predisposed individuals.

Ekelund, Ulf
Dr Ulf Ekelund is working with EPIC-Norfolk data and looking at the effects of physical activity and sedentary behaviour and their affects on health, as well as developing different methods for assessing physical activity.

Ellegard, Lars
Dr Susan Andersson and Dr Lars Ellegard, of Department of Clinical Nutrition, Sahlgrenska Academy at Göteborg University, Sweden have worked with EPIC to look at how plant sterol intake from naturally occurring dietary sources impacts on the concentrations of blood lipids.

Forouhi, Nita
Dr Nita Forouhi is leading in investigating the role of diet and nutrition in the risk of developing diabetes, obesity and obesity-related disorders, and working with EPIC-Norfolk to further develop methods of assessment of diet.

Foster, Paul
Mr Paul Foster of Institute of Ophthalmology is leading on the visual health component of the Third Health Check. Mr Foster is working on the EPIC data to investigate the links between diet, lifestyle and environment and eye disease (in particular glaucoma and age-related macular degeneration) as well as possible gene-environment interaction.

Friesen, Martin D
Dr Marlin D Friesen, currently at John Hopkins Bloomberg, School of Public Health, worked in the early stages on the development and validation of the methods to analyse fatty acids from bloods collected at the first and second health checks.

Fruchart, Jean-Charles
Dr Jean-Charles Fruchart of Pasteur Institute, Lille, France has investigated the molecular mechanisms of Apolipoprotein and other novel risk factors in Chronic Heart Disease and Diabetes Type 2.

Griffin, Simon
Dr Simon Griffin is the group leader in disease prevention and has examined EPIC-Norfolk data in relation to risk scores.

Guralnik, Jack
Dr Jack M Guralnik is a Senior Investigator of the Epidemiology and Demography Section from the National Institute of Aging.  Dr Guralnik's work includes the study of the effects of chronic disease on functional limitations, disability, and the ability to remain independent.  Dr Guralnik has worked data on lower extremity performance using the Established Population for Epidemiologic Studies of the Elderly (EPESE) battery including gait speed, chair stands, and tandem balance tests, which is a major component of the current EPIC-Norfolk Third Health Check.

Along with Professor Melzer, Dr Guralnik is collaborating on work to search for candidate genes for effects on physical and cognitive function in older people and their effect on ageing.


Hart, Andrew
Dr Andrew Hart and colleagues from the University of East Anglia are involved in follow-up of the EPIC cohort investigating the incidence of lower gastro-intestinal (GI) tumours and gallstones.  Additionally, Dr Hart has assembled an international EPIC collaboration to study Crohns disease.

Hogervorst, Eva
Professor Eva Hogervorst currently holds the position of Chair of (Biological) Psychology at the University of Loughborough. Professor Hogervorst's work has included assessment of early differential dementia diagnostics using computerized systems and investigating modifiable risk and protective factors for dementia and age-related cognitive decline. As part of the Third Health Check, we are using a number of quick, easy-to-administer and well-tolerated tests developed by Professor Hogervorst to test performance in different cognitive domains.

Humphries, Steve Eric
Professor Steve Humphries from University College, London is working with EPIC-Norfolk on cardiovascular genetics.

Huppert, Felecia
Professor Felicia Huppert, from Cambridge Interdisciplinary Research Centre on Ageing - CIRCA, University of Cambridge is working on the area of Positive Psychology and wellbeing.

Kastelein, John JP
Professor John J P. Kastelein is leading the EPIC-Norfolk collaboration in the area of molecular biology of cholesterol transport, and in particular in investigating the role of Cholesteryl ester transfer protein (CETP) and Cardiovascular Disease risk.

Key, Tim
Professor Tim Key, a cancer epidemiologist, is the principal investigator with EPIC-Oxford where he has been since 1985.  Professor Key's study focuses primarily on vegetarians, vegans, and healthy eaters.  Like the EPIC-Norfolk cohort, EPIC-Oxford collaborates with the CNC and uses food diaries.

Kuhnle, Gunter G
Dr Gunter Kuhnle's work focused on the mechanism underlying the link between red meat and cancer, associations between phytoestrogens and cancer and the development of new nutritional biomarkers.  He is now using biomarker to analyse the sugar intake in EPIC-Norfolk.  Before joining Professor Sheila Rodwell's (also known as Bingham) Diet & Cancer group at the MRC Dunn Human Nutrition Unit in Cambridge, Dr Kuhnle worked in London on the metabolism of flavonoids in the Antioxidant Research Group at King's College.

Langenberg, Claudia
Dr Claudia Langenberg is working with EPIC-Norfolk as part of the wider European study, in the coordination of the InterAct project.

Loos, Ruth
Dr Ruth Loos and her group are working with EPIC data in the identification of genes that contribute or predispose to the risk of developing obesity and obesity-related conditions, and to explore the influence of environmental factors in the development of obesity in individuals with these genes.

Melzer, David
Professor David Melzer from the Peninsula Medical School, Exeter is working with EPIC-Norfolk data on risk factors of ageing with particular focus on functional health.

Michels, Karin
Karin Michels, Associate Professor in the Department of Epidemiology at Harvard's School of Public Health, completed a PhD at Cambridge in 2005.  Collaborating with EPIC-Norfolk through Professor Nick Day, Dr Michels examined the role of measurement error models and biostatistics.

Ong, Ken
Dr Ken Ong is involved with EPIC-Norfolk examining childhood growth and obesity.  Most recently, he has examined the relationship between age at puberty and genetic markers in EPIC-Norfolk.

O'Rahilly, Stephen
Stephen O'Rahilly is Professor of Clinical Biochemistry and Medicine and the Director of the Metabolic Research Laboratories at the Institute of Metabolic Science (IMS).  Professor O'Rahilly has collaborated with EPIC-Norfolk on the work on the genetic basis of obesity and type 2 diabetes.

Otvos, James
Dr James Otvos, Raleigh, USA is involved in using nuclear magnetic resonance (NMR) spectroscopy to look at the association of lipoproteins and coronary artery disease.

Pharoah, Paul
Dr Paul Pharoah from the Department of Oncology, University of Cambridge is also using samples from female EPIC-Norfolk participants as controls to investigate the polygenic susceptibility to cancer, particularly to breast cancer and trying to identify and study the interaction of genetic variants with each other and with the environment.

Ponder, Bruce
Under the direction of Professor Bruce Ponder (currently at Cancer Research UK, Cambridge Research Institute), researchers from the Department of Oncology have done a huge amount of work on breast and ovarian cancer in particular, especially the role of BRCA1 and 2 genes using EPIC-Norfolk data as control for their dataset. The group continues to look at the genetics of these diseases investigating further the spectrum of BRCA1 and 2 mutations, links with environmental modifiers, interventions for family members at risk and how genetic differences between people change the way they respond to cancer treatments.

Reeve, Jonathan
Dr Jonathan Reeve, Department of Medicine, University of Cambridge and Dr Ian Bruce ARC Epidemiology Unit, School of Epidemiology & Health Sciences, University of Manchester, headed the European Prospective Osteoporosis Study (EPOS). EPOS was a sub study of EPIC using EPIC participants to investigate the role of several key lifestyle risk factors on the occurrence of fractures, the contribution of bone mineral density and evaluated the outcome following spinal fracture both in terms of morbidity and mortality.

Reitsma, Pieter H
Dr Pieter H Reitsma, Department of Thrombosis and Hemostasis, Leiden University Medical Center, The Netherlands, is working with the EPIC-Norfolk group to investigate the role of certain inflammatory markers, such as IL10, MCP-1, IL8 in cardiovascular disorders.

Riboli, Elio
Professor Elio Riboli, currently the Chair of Cancer Epidemiology, Imperial College, London is one of the key researchers who initiated the wider European EPIC project. As the coordinator of EPIC (Europe), Professor Riboli is responsible for coordinating the research projects from all the coordinating centres in EPIC who are investigating  the role of nutrition, lifestyle, environment, genetics and metabolic and hormonal factors in the etiology of cancer and chronic disease.

Sahakian, Barbara
Professor Barbara Sahakian from the Department of Psychiatry, University of Cambridge is the co-inventor of the CANTAB computerised neuropsychological tests which are used as part of the cognitive battery in the Third Health Check.

Sandhu, Manj
Dr Manjinder Sandhu is an epidemiologist in the Department of Public Health and Public CareUniversity of Cambridge.  Since being one of EPIC's first PhD students, Dr Sandhu has gone to study the genetic epidemiology of chronic diseases.  His team includes Sally Debenham and Sophie Ashford.

Schatzkin, Arthur
Dr Arthur Schatzkin, Chief of the Nutritional Epidemiology Branch and Senior Investigator with the National Cancer Institute (USA), was a collaborator to the late Professor Sheila Rodwell's research (published as Sheila Bingham).  This collaboration with EPIC-Norfolk concerned error in dietary assessment.

Shuker, David
Professor David Shuker of the MRC Toxicology Unit, University of Surrey has worked with EPIC looking at biomarkers of dietary exposures in particular, looking at DNA damage in relation to these dietary exposures.

Surtees, Paul
Dr Paul Surtees and Dr Nick Wainwright of the Social Epidemiology group at Strangeways Research Laboratory are interested in improving understanding of the relationship between psychosocial factors and health. The team is looking at how our mood, anxiety and stress has an effect on different disease and health outcomes.

Symmons, Deborah
Professor Deborah Symmons and Dr Ian Bruce of the Arthritis Research Campaign (ARC) Epidemiology Unit, University of Manchester, have used EPIC dietary data collected at baseline to see whether there is an association between consumption diet and the risk of developing inflammatory polyarthritis (IP).

Todd, Chris
Professor Chris Todd, School of NursingUniversity of Manchester also contributed to EPOS, looking at bone health and risk fracture.

Varki, Ajit
Professor Ajit Varki, from the School of Medicine, University of California, San Diego worked with EPIC-Norfolk in the early stages to look at the association of salic acid, anti Neu5Gc from our diet (particularly from red meat and dairy products) that could contribute to the inflammatory processes and cause chronic diseases, such as heart disease, diabetes and cancer.

Wainwright, Nick
Dr Paul Surtees and Dr Nick Wainwright of the Social Epidemiology group at Strangeways Research Laboratory are interested in improving understanding of the relationship between psychosocial factors and health. The team is looking at how our mood, anxiety and stress have an effect on different disease and health outcomes.

Warren, Ruth
Dr Ruth Warren, Department of Radiology, University of Cambridge is working with us to look at risk factors associated with mammographic breast density and breast cancer risk.

Witztum, Joseph
Professor Joseph Witztum of Faculty of the Division of Endocrinology & Metabolism, University of California, San Diego has worked with EPIC-Norfolk to investigate the role of oxidation of lipoproteins in atherosclerosis.

Wong, Man-Yu
Man-Yu Wong, Associate Professor at the Hong Kong University of Science and Technology, is a statistician who collaborated with EPIC-Norfolk through Professor Nick Day on work concerning measurement error models.


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last updated: 20 November 2011